Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. These reactions may occur if you have an allergy to milk thistle. Dupuis ML, Conti F, Maselli A, et al. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. J Diabetes Res. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. 3 are moderate, and 1 is minor. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Take this product by mouth as directed. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. Learn more about the other negative effects of this herb and what research says about them. How long does it take for milk thistle to start working? It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. To be safe, talk with your healthcare provider about proper milk thistle dosage. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. Phytother Res. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Is the ketogenic diet right for autoimmune conditions? Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. Vegetable Oil: Nutrition Facts And Differences. If you have any questions about storage, ask your pharmacist. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. For this reason, it is important to buy milk thistle from reputable retailers. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Please review supplement labels with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Milk thistle is a herbal product widely used in the United States and around the world. jaundice. Things to remember when you fill your prescription. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. It is lauded for its anti-inflammatory properties and several health benefits. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Keep all medications and herbal products away from children and pets. He specializes Professional Certificate In Food, Nutrition & Health. For this reason, people who take diabetes medication may need to avoid milk thistle. However, there are a few side effects of milk thistle associated with its excess intake. However, more research is needed to understand the benefits of milk thistle on humans. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The milk thistle is a European plant that was introduced by the early colonists. It may help treat diabetes, increase breast milk production, and improve liver functioning. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Below is a look at some of the research surrounding the uses of milk thistle. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. The milk may have fallen on the leaves, leaving white marks. The name milk thistle is associated with the legend of Mother Mary. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Hence, stay safe and avoid use. Researchers think it may also slow down the growth of cancer cells. Deng JW, Shon JH, Shin HJ, et al. We encourage you to discuss any decisions about treatment or care with your health care provider. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Cochrane Database Syst Rev. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. Continue reading. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. It also looks at how to use milk thistle and whether there are any risks to consider. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. However, more direct research is warranted in this regard. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Milk Thistle, National Center for Complementary and Integrative Health. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. These combination supplements may list health claims on the label. It may not be safe for people with hormone-sensitive breast cancer. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Can you drink alcohol while taking milk thistle? Milk thistle can also cause an allergic reaction in some people. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Last medically reviewed on December 17, 2021. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Is there also a role for herbs and supplements? List Milk Thistle Capsule side effects by likelihood and severity. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. What Are the Side Effects of Milk Thistle? Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. 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